MELASMA, just typing the word makes me cringe. This challenging condition has kept skin experts on their toes for years.
The question is, what's the best treatment option and is that option or options going to show temporary effect, is it possibly going to make it worse, can my patient even have this treatment, and the list goes on.
I could bore you with the science of Melasma and the causes, but what's the point. If you've been in skin care for a minute, you know its one of your most challenging issues to address.
Instead, I will link you to a novel study proposing that the cause of Melasama may largely be due to senescent fibroblasts and the break down of the basement membrane in the dermal epidermal junction (dej).
PW_Pigmentation_Senescent fibroblasts drive ageing pigmentation A potential therapeutic target for senile lentigo.pdf